|
KMID : 0614620210780050268
|
|
Korean Journal of Gastroenterology
2021 Volume.78 No. 5 p.268 ~ p.283
|
|
|
Up-to-date Knowledge on the Pathological Diagnosis of Hepatocellular Carcinoma
|
|
Nahm Ji-Hae
Park Young-Nyun
|
|
|
Abstract
|
|
|
|
Hepatocellular carcinoma (HCC) has heterogeneous molecular and pathological features and biological behavior. Large-scale genetic studies of HCC were accumulated, and a pathological-molecular classification of HCC was proposed. Approximately 35% of HCCs can be classified into distinct histopathological subtypes according to their molecular characteristics. Among recently identified subtypes, macrotrabecular massive HCC, neutrophil-rich HCC, vessels encapsulating tumor clusters HCC, and progenitor phenotype HCC (HCC with CK19 expression) are associated with a poor prognosis, whereas the lymphocyte-rich HCC subtype is related to a better prognosis. This review provides up-to-date knowledge on the pathological diagnosis of HCC according to the updated World Health Organization Classification of Digestive System Tumors 5th ed.
|
|
|
KEYWORD
|
|
|
Carcinoma, hepatocellular, Subtype, Pathology, Molecular classification
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|